产品货号：
Z38676
中文名称：
Gelsolin/GSN抗体
英文名称：
Anti-Gelsolin/GSN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Gelsolin/GSN Antibody |
| 指标别名 | Actin depolymerizing factor;ADF;AGEL;Brevin;Gelsolin;GSN |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | GSN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Gelsolin Calcium-regulated,actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments,preventing monomer exchange (end-blocking or capping).It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.Plays a role in ciliogenesis. |
| 实际分子量 | 86KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Gelsolin,also known as GNS or brevin,is an actin-binding protein that is a key regulator of actin filament assembly and disassembly.Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily.The gene was assigned to human chromosome 9q33.2.It is the principal intracellular and extracellular actin-severing protein.Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis.Gelsolin may have therapeutic potential as a mucolytic agent in CF patients.The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol. |
| Uniprot ID | P06396 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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